The biggest obstacle to Trump's agenda is not the US House crazies. The Nancy Pelosi obstruction of Trump's first term will not happen.
The problem is the Senate, particularly Senate Republicans. These creatures ARE the swamp. This is the wannabe ruling class power brokers who have much to lose from Trump's team running roughshod over the Federal bureaucracy.
The first indication of trouble came with the election of S. Dakota Senator Thune. The man does not have the backbone or smarts to whip his Senate colleges into compliance. He's already caved on recess appointments. Thune is certainly better than the reptile Senator John Cornyn, but he's a far cry from MAGA supporter Senator Rick Scott.
The Senate majority leader election showed that the Senate Republicans don't want much to change. Is that a problem? I think so because a chunk of the Biden legislation needs to be repealed. E.g. do you really want your next car to have a backdoor kill switch that authorities can use whenever without a warrant or due process? These are the same idiots that fired people for not getting vaxed, locked down schools, etc. Well that backdoor kill switch was mandated by Brandon, although I doubt he knew it.
What about the very obvious changes needed to the FDA? Do you think the non-MAGA Senate reptiles are going to give up all that Big Pharma money just because Robert Kennedy says so?
Gonna be a rough couple years IMO.